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An era in which an Alzheimer’s (阿尔兹海默) diagnosis can begin in a doctor’s office is now arriving. Advances in technologies to detect early signs of disease from a blood sample are helping doctors to identify the memory-robbing disorder more accurately and to screen participants more quickly for trials of potential treatments for the more than five million people in the U.S. afflicted with Alzheimer’s. Estimates predict that, by 2030, there will be 76 million people worldwide who will receive a diagnosis of Alzheimer’s or other dementias.

Last fall, a blood test developed by C2N Diagnostics in St Louis, Mo., became available to most of the U.S. as a routine lab test—regulated under the CMS Clinical Laboratory Improvement Amendments (CLIA) program. It has also received a CE mark as a diagnostic medical device in the European Union—indicating it has met safety, health and environmental protection standards for the region.

“The development of a blood-based test for Alzheimer’s disease is just phenomenal,” says Michelle Mielke, a neuroscientist and epidemiologist at the Mayo Clinic. “The field has been thinking about this for a very long time. It’s really been in the last couple of years that the possibility has come to fruition.”

The C2N test, called PrecivityAD, uses an analytic technique known as mass spectrometry (质谱分析技术) to detect specific types of beta-amyloid (β-淀粉样蛋白), a protein fragment that is a pathological (病态的) hallmark of disease. Beta-amyloid proteins accumulate and form plaques (斑块) visible on brain scans two decades before a patient notices memory problems. As plaques build up in the brain, levels of beta-amyloid decline in the surrounding fluid.

Such changes can be measured in spinal (脊髓的) fluid samples—and now in blood, where beta-amyloid concentrations are significantly lower. PrecivityAD is the first blood test for Alzheimer’s to be cleared for widespread use and one of a new generation of such assays that could enable early detection of the leading neurodegenerative disease—perhaps decades before the onset of the first symptoms.

【小题1】According to the blood test developed by C2N Diagnostics, we can know that ________.
A.it can be applied in a few areas in the United States
B.it was carried out under the supervision of under the CMS’s program
C.it obtained the CE mark issued by the United States for diagnostic medical equipment
D.it has reached the safety, health and environmental protection standards of the world
【小题2】What is MichelleMielke’s attitude towards blood test?
A.Supportive.B.Opposed.C.Cautious.D.Wait-and-see.
【小题3】Which of the following best explains “assays” underlined in the last paragraph?
A.samplesB.experimentsC.changesD.symptoms
【小题4】From the passage, it can be inferred that ________.
A.by 2030, more people around the world will suffer from Alzheimer’s disease or other dementia
B.as plaques accumulate in the brain, the level of beta-amyloid protein in the surrounding fluid will rise
C.Alzheimer’s patients are expected to be diagnosed decades before the initial symptoms appear
D.many blood tests for Alzheimer’s disease are under development now
2024·甘肃张掖·一模
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Pioneers like Harvard social ecologist Stephen Kellert were among the first to champion modern biophilic design. Kellert believed that weaving nature into living and workspaces is critical for good physical and mental health.

Humans have evolved to gravitate towards nature, Kellert noted. His principles include access to natural light, air, water, and plants. Using materials such as wood and stone, biophilic designs such as leaf or shell patterns help humans to feel closer to nature.

Biophilic designs can be seen all over the world. Examples include the Changi Airport in Singapore, with its four-storey forest garden and world’s largest indoor waterfall fed by rainwater, and the Swedish Mirror Cube Tree House Hotel, mainly made of used plywood and a lightweight aluminum frame wrapped around a tree. Incredible biophilic homes include One Central Park in Sydney, apartment blocks featuring hanging gardens on the outside. The buildings recycle their own water and a suspended (悬浮的) motorized mirror system reflects sunlight down onto gardens below. Milan’s Bosco Vertical block is perhaps even more eye-catching with its vertical forest.

Putting biophilic design to work for society could prevent millions in healthcare costs, with one study estimating annual savings of $93 million in the US alone. Hospital design in particular has historically been influenced by access to sunlight and views of nature. Modern buildings like the Khoo Teck Puat Hospital in Singapore, with its position next to the waterfall of the Yishun Pond, are closely linked with their surroundings. The hospital channels outdoor air to cool the inside, and uses reflective sunshades to direct light into the wards to brighten them and save energy.

The aim of these designs is to emphasize the human connection to nature by integrating buildings with the local environment. But how do we bring biophilia into our homes? Start with house plants. New smart home apps can also provide sensory nature experiences such as birdsong and a projected forest canopy, helping people to carve out a restful space indoors.

But perhaps the best way to transform society with biophilic designs is to start with schools. Children learn better and feel more relaxed in biophilic settings. So the Children and Nature Network is working with schools across the US to create green schoolyards for better physical and mental health and to increase opportunities for outdoor learning.

Biophilic designers are bringing nature into classrooms through natural patterns, shapes and colors, nature photography, artwork and materials like timber and stone. Fresh air flow, green walls, and aquariums all become part of a recipe for improving health and academic success.

【小题1】According to the passage, what does Stephen Kellert probably believe?
A.Humans’ inborn love for nature won’t be lessened.
B.Nature can improve people’s sense of responsibility.
C.Humans need to appreciate and make good use of nature.
D.Natural materials have taken priority in modern building designs.
【小题2】What do the examples of biophilic designs in the passage have in common?
A.They apply smart home technology.
B.They promote sustainable development.
C.They include waterfalls and gardens inside.
D.They use local resources to cut the cost of buildings.
【小题3】What can we learn from the last two paragraphs?
A.Biophilic designs have greatly transformed schools.
B.Biophilic designs help improve students’ performance.
C.Biophilic designs focus mainly on students’ mental health.
D.Biophilic designs have moved most of the classrooms outside.
【小题4】Which of the following would be the best title for the passage?
A.Let’s Invite Nature Inside
B.Live Naturally and Simply
C.The Best Natural Building Designer
D.Ups and Downs of Natural Buildings

Microsoft has developed a new smartphone app that interprets eye signals and translates them into letters, allowing people with motor neurone disease to communicate with others from a phone.

The GazeSpeak app combines a smartphone’s camera with artificial intelligence to recognize eye movements in real time and convert them into letters, words and sentences.

For people suffering from ALS(渐冻症), also known as motor neurone disease, eye movement can be the only way they are able to communicate.

“Current eye-tracking input systems for people with ALS or other motor impairments are expensive, not robust under sunlight, and require frequent re-calibration (重新校对) and substantial, relatively immobile setups,” said Xiaoyi Zhang, a researcher at Microsoft who developed the technology.

“To mitigate the drawback,we created GazeSpeak, an eye-gesture communication system that runs on a smartphone, and is designed to be low-cost, robust, portable and easy to learn.”

The app is used by the listener by pointing their smartphone at the speaker. A chart that can be stuck to the back of the smartphone is then used by the speaker to determine which eye movements to make in order to communicate.

The sticker shows four grids of letters, which each correspond to a different eye movement. By looking up, down, left or right, the speaker selects which grids the letters they want belong to. The artificial intelligence algorithm(计算程序) is then able to predict the word or sentence they are trying to say.

【小题1】Who is the smartphone app designed for?
A.People with motor eye disease.
B.People suffering from eye communication.
C.People with problems in intelligence.
D.People suffering from motor neurone disease.
【小题2】The underlined word “mitigate” in the fifth paragraph probably means ________.
A.relieveB.get rid of
C.removeD.find
【小题3】According to the text, ________.
A.for people suffering from ALS, eye movement is one of the best ways to communicate.
B.a new communication system that runs on a smartphone is designed to be immobile.
C.the speaker could use the app by pointing their smartphone at the listener.
D.the artificial intelligence algorithm will translate sentences for speakers.

Unlike produce such as peaches or bananas, strawberries begin to decline as soon as they are picked. Scientists have been working on a special protection that delays spoilage by slowing water loss and oxidation (氧化).

Every fruit and vegetable breathes. Once a piece of produce is picked from a tree or plant, it continues to breathe, aging slowly, until it begins to break down. Microorganisms then move in, causing it to spoil. Refrigeration can delay the process, but only so much.

Some scientists now think they can make your bananas, avocados, and other fresh produce last up to twice as long by delaying spoilage. Apeel, a start-up in Santa Barbara, California, has created a way to remove lipids from several popular crops and transform each type into a powder. Dissolved in water and applied to fruits or vegetables, it forms an edible(可食用的) barrier to lock moisture in and microorganisms out.

Farmers can apply a version of the solution in the field, or distributors can use the rinse (冲洗) on the packing line, extending a fruit’s shelf life by days or even weeks. The FDA recognizes the process as safe, and earlier this year it was approved for use on organic produce.

Giving shoppers more time with their fresh food is one purpose. But Apeel’s higher goal is to fight food waste and reduce the number of refrigerated trucks and ships that race between fields and stores to deliver food at its peak. The technology can also allow more crops to be delivered to more places farther and farther from where they’re grown. “You can imagine a world without seasonality of fresh produce,” says James Rogers, Apeel’s CEO and a materials scientist.

In the meantime, who couldn’t use a few extra days before that fruit in the fridge starts to mold?

【小题1】What has the company, Apeel, invented?
A.A strategy to fight food waste by mixing fruits or vegetables with crops.
B.A solution to get rid of what causes fresh fruits or vegetables spoil.
C.A method to remove crop lipids and change them into nutritious powder.
D.A way to lock moisture in and microorganisms out by forming an edible barrier.
【小题2】According to the passage, which of the following is NOT true?
A.Fruits and vegetables picked from trees can go bad easily without any protection.
B.Scientists are aimed at a new way to prevent fresh produce from molding soon.
C.Farmers and distributors can use what Apeel has created but it proves unsafe.
D.Shoppers are among those who can benefit a lot from Apeel’s new idea.
【小题3】What do James Rogers’s words mean?
A.Every fruit and vegetable will stay fresh all year around in the future.
B.The food fresh keeping technology contributes to long-distance transporting.
C.You can get any fresh produce in any season in the future.
D.You can use the fridge to store the fresh produce for a longer time.

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