When colds and flu hit, many people automatically turn to over-the-counter (OTC) medicines to push through and treat their symptoms. Although these medicines are easily accessible and widely used, it might come as a surprise to many people to learn that they are not risk-free. A study estimated that every year, 26,735 people went to the emergency room for adverse (不利的) events related to OTC cold and cough medicines.

When two or more drugs are used together, their interactions can sometimes produce unexpected harmful effects. Physicians are typically knowledgeable about potential drug interactions, so it is very important for patients to ask their healthcare providers which OTC medicines are safe for them to use.

It is important to read the package ingredients of OTC medicines closely to avoid duplication of doses (剂量重复). Cold medicines are typically made up of multiple ingredients. A person who takes a single-ingredient medicine paired with one of these multi-ingredient medicines can receive an unsafe dose of that ingredient.

While everyone could potentially experience adverse effects from cold and flu medicines, some groups — including older adults, children and pregnant women — may be at greater risk. Older people who are using prescribed drugs to treat multiple health conditions may have a higher risk of drug interactions because of the higher number of medicines being used at the same time to treat different conditions. The aging body is not as expert at absorbing, distributing and clearing medicines as younger bodies are. This can put older adults at higher risk for an overdose and drug-to-drug interactions with some medicines.

The Food and Drug Administration and the Centers for Disease Control and Prevention do not recommend giving cold medicines to children under age 4. Because of a variety of factors, young children have a higher risk of an accidental overdose and adverse events that could lead to death.

In the winter of 1910, Dr. Wu Lien-Teh stepped off a train in the northern Chinese city of Harbin. He was there to solve a medical mystery, at great personal risk. Over the past few months, an unknown disease had swept along the railways of northeast China, killing 99.9% of its victims. The Qing Imperial court had sent the Cambridge-educated Dr. Wu north to stop the epidemic.

When Dr Wu arrived in Harbin on Christmas Eve, 1910, he carried little in the way of medical instruments and had only one assistant. One of Wu' s first acts upon arrival was to set up special quarantine(隔离) units and to order lockdowns to stop infected persons from traveling and spreading the disease. He had teams check households for possible cases, and even managed to convince authorities to completely close the railways in the early weeks of 1911. Of particular concern was the upcoming Chinese New Year holiday, which had become a great annual migration of people traveling across the country to see their families.

Thanks to Dr. Wu's efforts, the number of plague victims began to die down, and by March 1, 1911, the epidemic was fully contained. The pneumonic (肺炎的) plague outbreak of 1910-1911 lasted nearly four months, affected five provinces and six major cities, and accounted for over 60,000 deaths. It is clear that without the brave and decisive actions taken by Dr. Wu, it could have been much worse. Had the epidemic gone unchecked, allowing holiday rail passengers to spread the disease to the rest of China could have meant a catastrophic loss of life and possibly a global health crisis.

In April 1911, Dr. Wu chaired an International Plague Conference in Shenyang, attended by scientists from 11 counties including the United States, Great Britain, Russia, Japan and France. They praised Dr. Wu for his handling of the 1910-1911 outbreak. For a time, Dr. Wu was the world's most famous plague fighter, a title be defended in a malaria epidemic in China in 1919, and a return of plague in 1921.

A brain implant allowed people with head injuries to function again. The deep brain stimulation implant, developed by researchers at Stanford University, aims to boost activity between the regions responsible for consciousness learning, memory, thinking and problem solving.

During the early trial, five people with brain injuries reported they were able to concentrate, read, remember and drive properly. The trial proved so effective that researchers had trouble completing the final stage, which was to switch off the device for three random participants after two of the patients declined.

Gina Arata, a trial participant, said, “I couldn’t remember anything. My left foot dropped, so I’d trip over things all the time. I was always in car accidents. Since the implant, I haven’t had any speeding tickets. I don’t trip anymore. I can remember how much money is in my bank account.”

Researchers selected patients for the trial who had recovered from comas (昏迷) with brain systems believed to be still well preserved, but not functioning as well as previously. “In these patients, those pathways are largely complete, but everything has been down-regulated (下降),” said Dr Jaimie Henderson, a professor of neurosurgery. “It’s as if the lights had been darkened and there just wasn’t enough electricity to turn them back up.” The researchers hoped that precise electrical stimulation of specific areas could turn the “lights” back up, and created a virtual model of each participant’s brain so they could trial stimulation at different locations ahead of surgery.

Guided by the theory, Dr Henderson implanted the device in the five participants who had sustained injuries between three and 18 years earlier. After allowing the device to bed-in for two weeks, the participants spent 90 days with it turned on for 12 hours a day. At the end of the 90-day treatment period, the participants had improved their mental processing speeds by an average of 32 percent.

“This is a pioneering moment,” said Dr Nicholas Schiff, co-senior author of the study. “Our goal now is to try to take the systematic steps to make this a therapy (疗法). This is enough of a signal for us to make every effort.”