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Sleep disturbances can be an early sign of Alzheimer’s disease (阿尔茨海默病). Many people eventually diagnosed (诊断) with Alzheimer’s start experiencing difficulty falling and staying asleep years before cognitive problems such as memory loss and confusion appear. It’s a vicious cycle: Alzheimer’s disease involves changes to the brain that interrupt sleep, and poor sleep accelerates harmful changes to the brain.

Researchers at Washington University School of Medicine in St. Louis have identified a possible way to help break that cycle. A small, two-night study has shown that people who took a sleeping pill before bed experienced a drop in the levels of key Alzheimer’s proteins — it’s a good sign, since higher levels of such proteins coexist with more serious disease.

The study, which involved a sleeping aid that is already approved by the Food and Drug Administration (FDA) for insomnia (失眠), indicates the potential of this sleeping pill to slow or stop the progression of Alzheimer’s disease, although much more work is needed to confirm the practice of such an approach.

“This is a small, proof-of-concept study. It would be premature for people who are worried about developing Alzheimer’s to interpret it as a reason to start taking this sleeping pill,” said researcher Brendan Lucey, director of Washington University’s Sleep Medicine Center. “We don’t yet know whether long-term use is effective in delaying cognitive decline, and if it is, at what dose and for whom. Still, these results are very encouraging. This drug is already available and proven safe, and now we have evidence that it affects the levels of proteins that are vital for driving Alzheimer’s disease.”

“I’m hopeful that we will eventually develop drugs that take advantage of the link between sleep and Alzheimer’s to prevent cognitive decline,” he continued. “We’re not quite there yet.”

【小题1】Which can best replace the underlined word “vicious” in paragraph 1?
A.Bad.B.Rare.C.Normal.D.Complete.
【小题2】What can we learn about key Alzheimer’s proteins?
A.They are the cause of insomnia.B.They can make the disease worse.
C.They reflect changes in the brain.D.They are controlled by sleeping pills.
【小题3】What’s Brendan Lucey’s attitude towards taking a sleeping pill to prevent Alzheimer’s?
A.Supportive.B.Uncertain.
C.Cautious.D.Doubtful.
【小题4】Which can be a suitable title for the text?
A.Sleep Disturbances Indicate Alzheimer’s
B.Drugs for Alzheimer’s Are Being Developed
C.Alzheimer’s Is Linked with Cognitive Decrease
D.A Sleeping Pill Reduces Levels of Alzheimer’s Proteins
2023·全国·模拟预测
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If you were on the street in Mexico today you might think you were in an operating room, surrounded by doctors. You could see many concerned people with masks (口罩) trying their best to stop the swine flu (猪流感). And the masks aren’t only being used in Mexico. A friend of mine traveling from New York City to Florida was given a mask and a pair of gloves just after he reached the airport. And another friend went to get a haircut only to be faced with a hairdresser wearing a mask!

But do the masks really work? Is covering your nose and mouth the key to stopping the swine flu? To find out the truth, ABC’s reporter Sharyn Alfonsi talked with germ (细菌) expert Dr. Elaine Larsen. It turns out that when you sneeze (打喷嚏) the air coming out of your mouth at a speed of one hundred miles per hour carries germs which can travel anywhere around you and make people around you infected (被感染).

However, whether you become infected actually depends on the weather. As Sharyn reported, when you sneeze, the germs leave your body in small drops of water coming out of your mouth. If the weather is wet, the wet air will make the small drops bigger and heavier and they drop down towards our feet. If this happens, we won’t become infected. But if the air is dry, those small drops can float higher up, making it possible for them to touch someone else’s nose, mouth or their mask.

Larsen says the masks can stop the germs well but after a few hours, they start to get wet, holding a lot of germs they come across and causing you to breathe them in. The masks do work, but the key to stopping the germs is changing your masks often.

【小题1】According to Para.1, in Mexico you can see that ____.
A.the patients are treated in the open air
B.some doctors work in the street
C.people speak little to each other in the street
D.many people wear masks in the street
【小题2】According to the passage a patient spreads germs mainly through ____.
A.breathingB.Speaking
C.touching othersD.sneezing
【小题3】We learn from the passage that on a wet day ____.
A.sick people will be infectedB.germs can spread very far
C.germs spread very quicklyD.few people will be infected
【小题4】If you keep wearing a mask for a long time, ____.
A.the mask will be old and worn outB.you’ll love the feeling of wearing it
C.germs will be kept away from youD.it will be easy for you to be infected
【小题5】What should we pay attention to when wearing masks?
A.Keeping the masks dry.B.Changing the masks often.
C.Choosing very thick masks.D.Wearing big masks.

An estimated 5. 7 million people in the U. S. have Alzheimer's disease. The most common type of dementia(痴呆) -and that number is expected to more than double by 2050. Early diagnosis (诊断) is fundamental for patients to benefit from the few therapies available. But no scans can deliver a conclusive diagnosis while a person is alive; instead doctors have to conduct numerous and complicated clinical and neuropsychological tests. So there is growing interest in developing artificial intelligence to identify Alzheimer's based on brain imaging.

Researchers at the University of Califormia, San Francisco have now successfully trained an AI algorithm (算法) to recognize one of the early signs of Alzheimer's-a reduction in the brain's glucose(葡萄糖) consumption- in positron emission tomography(pet) imaging.

The algorithm accurately predicted an eventual Alzheimer's diagnosis in nearly all the test cases, d according to the study. In PET imaging, a very small amount of a radioactive compound are injected into the body, producing three-dimensional- images of metabolism(新陈代谢) circulation and other cellular activities. PET is well suited for an Al diagnostic tool because Alzheimer's leads to subtle changes in the oad0 brain's metabolism that begin years before neural tissue starts to go downhill, says study co-author Jae Ho Sohn, a radiologist at UCSF. These changes are "'very hard for radiologists to pick up. "he notes.

The algorithm was trained and tested on 2, 100 PET brain images from about 1, 000 people 55 years and older. The images came from a 12-year study that tracked people who were bound to be diagnosed with Alzheimer's, as well as those with mild memory declines and healthy control participants. The algorithm was trained on 90 percent of the data and tested on the remaining 10 percent. It was then retested on a second, independent data set from 40 patients monitored for 10 years. The algorithm was highly sensitive and was able to recognize 81 percent of the patients in the first test group and 100 percent in the second who would be diagnosed with Alzheimer's six years later, on average. The findings were published in February in Radiology.

The algorithm is based on "deep learning, a machine-learning technique that uses artificial neural networks programmed to learn from examples. "This is one of the first promising, initial applications of deep learning to the diagnosis of Alzheimer's, " says Christian Salvatore, a physicist at Italy's National Research Council, who was not involved in the study. "The model performs very well when identifying patients with mild or late diagnoses", he says, "but catching it in the earliest st ages remains one of the most critical open issues in this field. "

【小题1】People are increasingly interested in using to identify Alzheimer's because __________.
A.the number of people suffering from dementia is more than doubling
B.there are only a limited number of effective therapies for the patients
C.diagnosing Alzheimer's disease through Al is still an unexplored area
D.diagnostic methods that are both reliable and convenient are in need
【小题2】What's the best title for the text?
A.An AI Diagnostic Tool
B.Alzheimer's Al
C.PET Imaging
D.Artificial Neural Networks
【小题3】According to Paragraph 4, __________.
A.90% of the people in the study were trained on the algorithm
B.the algorithm managed to recognize all the patients in the second test group
C.81% of the people in the first test group were diagnosed with Alzheimer's
D.the participants in the study consist of people both young and old
【小题4】What can be inferred from Paragraph 5?
A.The algorithm serves as a promising treatment of Alzheimer's.
B.Deep learning has been widely applied in diagnosing Alzheimer's.
C.Whether to use the model to detect Alzheimer's remains a critical issue.
D.To detect Alzheimer's in its earliest stages calls for more exploration.

Have you ever heard of “children of the stars”? It might sound mysterious, but the expression refers to children with autism (自闭症). World Autism Awareness Day falls on April 2. It was initiated by the United Nations to raise awareness and promote acceptance of people with autism.

According to the US-based Autism Research Institute, autism is a disorder with symptoms (症状) that appear within the first three years of life. The condition is believed to involve deficits (缺陷) in social communication and interaction as well as restricted, repetitive behaviors, interests, or activities.

Meng Lingdi, whose daughter was diagnosed (诊断) with autism at 2 years old, shared that her daughter wouldn’t pay attention to her when Meng asked her to do something. “She made less eye contact with people compared to other kids,” Meng added.

Children with autism also suffer from physical pain. “Many children with autism experience epilepsy (癫痫) due to differences in brain activity,” said Sun Zhongkai at Beijing Stars and Rain Education Institute for Autism. Epilepsy among people with autism becomes even more prevalent (普遍的) starting from adolescence (青春期), he added.

At present, the precise cause of autism remains unknown, but research indicates that it is likely a result of a mix of developmental, genetic (遗传的), and environmental factors.

“According to our statistics, older parents are more likely to have autistic children than younger parents,” said Sun. “If the first child in a family has autism, the chances of subsequent children also having autism are about 10 times higher than in families where the first child is not autistic. The likelihood of identical twins both having autism is also significant.”

Although autism is a lifelong condition, there are various treatments available. According to Liu Wei, a teacher at the institute with 20 years of experience in teaching people with autism, it is crucial not to view people with autism with a sense of strangeness. Affirmations (肯定) from others will make them feel proud, enabling them to interact with others more effectively. For those close to autism sufferers, such as friends or family, it’s useful to establish certain principles for the individual, such as what is permissible and what is not. They should also have a deep understanding of autism and how to deal with it, which, for children with autism, may “benefit them for a lifetime,” said Sun.

【小题1】What is the purpose of the World Autism Awareness Day’s foundation?
A.To make people with autism easier to get various treatments.
B.To arouse people’s attention to autism and make people with autism easier to be accepted.
C.To make people with autism have a deep understanding of autism.
D.To enable people with autism to interact with others more effectively.
【小题2】What is autism primarily characterized by?
A.High anxiety.B.Sleeping disorders.
C.Communication difficulties.D.Exceptional athletic skills.
【小题3】What can we know about autistic children with epilepsy?
A.They are more active physically.B.They exhibit heightened sensitivity.
C.Their condition worsens with age.D.Their brain functions unusually.
【小题4】According to the text, which factor may be linked to an increased likelihood of having a child with autism?
A.Gender of the child.B.Age of the parents.
C.Education of the parents.D.Environmental pollution.
【小题5】How should we approach individuals with autism, according to the text?
A.Offer encouragement and support.B.Communicate our ideas clearly to them.
C.Be as generous as possible.D.Allow freedom in their choices.

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