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Delivering life-saving drugs directly to the brain in a safe and effective way is a challenge for medical providers. One key reason: the blood-brain barrier, which protects the brain from tissue-specific drug delivery. Methods such as an injection or a pill aren’t as precise or immediate as doctors might prefer, and ensuring delivery right to the brain often requires invasive, risky techniques.

A team of engineers from Washington University in St. Louis has developed a new nano-particle generation-delivery method that could someday vastly improve drug delivery to the brain, making it as simple as a sniff.

“This would be a nano-particle nasal spray, and the delivery system could allow medicine to reach the brain within 30 minutes to one hour,” said Ramesh Raliya, research scientist at the School of Engineering & Applied Science.

“The blood-brain barrier protects the brain from foreign substances in the blood that may injure the brain,” Raliya said. “ But when we need to deliver something there, getting through that barrier is difficult and invasive. Our non-invasive technique can deliver drugs via nano-particles, so there’s less risk and better response times.”

The novel approach is based on aerosol science and engineering principles that allow the generation of mono-disperse nano-particles, which can deposit on upper regions of the nasal cavity via spread. The nano-particles were tagged with markers, allowing the researchers to track their movement.

Next, researchers exposed locusts’ antenna to the aerosol, and observed the nano-particles travel from the antennas up through the olfactory nerve, which is used to sense the smell. Due to their tiny size, the nano-particles passed through the brain-blood barrier, reaching the brain and spreading all over it in a matter of minutes.

The team tested the concept in locusts because the blood-brain barriers in the insects and humans have similarities. “The shortest and possibly the easiest path to the brain is through your nose,” said Barani Raman, associate professor of biomedical engineering. “Your nose, the olfactory bulb and then olfactory cortex: two steps and you’ve reached the cortex.”

To determine whether or not the foreign nano-particles disrupted normal brain function, Saha examined the physiology response of olfactory neurons in the locusts before and after the nano-particle delivery and found no noticeable change in the electro-physiological responses was detected.

This is only a beginning of a set of studies that can be performed to make nano-particle-based drug delivery approaches more principled, Raman said. The next phase of research involves fusing the gold nano-particles with various medicines, and using ultrasound to target a more precise dose to specific areas of the brain, which would be especially beneficial in brain-tumor cases.

【小题1】What is the passage mainly about?
A.A novel method of drug delivery.B.A challenge facing medical staff.
C.A new medicine treating brain disease.D.A technique to improve doctor’s ability.
【小题2】What can we learn from the passage?
A.Doctors prefer using methods like an injection to treat diseases.
B.Locusts were tagged with markers to track their movement.
C.The blood-brain barrier lowers the effectiveness of a pill.
D.The medicine could reach the brain within half an hour.
【小题3】The researchers focused their study on locusts because        .
A.human and locusts have similar structures that protect brain from foreign substances
B.the delivery process consists of the olfactory bulb and the olfactory cortex
C.locusts have changeable electrophysiological responses to nanoparticles
D.the shortest and possibly the safest path to the brain is through human’s noses
2023·北京·三模
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Although vaccines are required for entry into school in most places in the United States, the government does allow for exceptions, like religious reasons.

In the last few years, the rates of vaccine-preventable illness have been on the rise. In most cases, these outbreaks began with children who were unvaccinated. To deal with this threat, some schools in New York have been refusing to allow unvaccinated children to attend school. Several parents thought this was unfair and filed lawsuits. Just recently, though, a court ruled in favor of the city schools.

The court made the right decision. Vaccine policy depends not only on the added protection that vaccines provide for those who get shots, but also on the decreased likelihood that anyone will come into contact with the disease. This is known as community immunity. It refers to the fact that when enough people are immunized, then there really can’t be an outbreak. And if there can’t be an outbreak, then everyone is protected.

This is important, because there are people who cannot be given immunizations for various reasons. For example, small babies can’t be given all vaccines.

In 1995, the chicken pox vaccine was introduced in the United States. Over time, more and more children received it. In 2011, a study looked at how the program affected the number of children who died from the disease.

The first thing noted in the paper was that death from chicken pox went down considerably after the vaccine was introduced. From 2001 through 2007, the rates of death remained much lower, with just a few children dying from chicken pox nationally each year.

What’s more from 2004 through 2007, not one child less than 1 year of age died in the United States from chicken pox. This is important, because we cannot give the chicken pox vaccine to babies. In other words, all those babies were saved not because we vaccinated them against this illness, but because older children were.

Therefore, people who refuse to vaccinate their children aren’t just putting themselves at risk — they’re putting everyone else in danger, too.

【小题1】Whose interest did the judges take into consideration?
A.Students’.B.School leaders’.C.Several parents’.D.Unvaccinated kids’.
【小题2】What is needed to prevent disease outbreaks through “community immunity”?
A.Requiring everyone to be immune.
B.Vaccinating babies as early as possible.
C.Making sure enough people get vaccinated.
D.Separating unvaccinated people from vaccinated.
【小题3】What does the study about the chicken pox vaccine show?
A.The vaccine is safe for every kid.B.No deaths have been seen since 2004.
C.The vaccine has lowered the death rate.D.The vaccine is more effective among babies.
【小题4】Which of the following would the author agree with?
A.No vaccine, no risk.B.No vaccine, no school.
C.Vaccination is a personal choice.D.Vaccine-preventable illness is dropping.

While I was teaching in China, I became interested in acupuncture (针灸). It was after returning from China and witnessing how successful it had been that I reached the decision to become an acupuncturist myself. I was lucky to discover that the town where I lived had a famous college of traditional acupuncture.

Alternative medicine such as acupuncture is particularly important for me because I firmly believe that it works on the level of body, mind and spirit. This is very different from Western medicine which is supposed to work only on the body. When a person is ill, it is believed that there’s something in their life that is putting their energy levels out of balance. What alternative therapies (疗法) try do to is kelp to gradually push that energy back into balance. The result is that any disease present might naturally disappear as it cannot survive when energies are balanced.

I’ve treated a wide range of people for various conditions, for example people suffering from stress and anxiety. To acquire a qualification in acupuncture, I took a course that lasted three years. I had to go to the college about one weekend in three. I also had a large amount of homework and practical work to do, which I did two or three evenings a week. This involved locating pints on different people. As you can imagine, this isn’t straightforward as people are of different sizes and have differently shaped bodies.

In the future I hope to set up an alternative health clinic which will involve myself as an acupuncturist but perhaps other people as well. I’d like to work with people who provide treatments such as rubbing (按摩) and pressing people’s feet in a special way to help them relax and feel well. I’d like to set it up somewhere in the countryside, where people could feel free from the stress of life.

【小题1】The author decides to learn acupuncture         .
A.when he was teaching in China
B.when he was studying in college
C.after he came back to his mother country
D.after he discovered an acupuncture school
【小题2】What does the author think of acupuncture?
A.It prevents disease.
B.It treats people as a whole.
C.It has an immediate effect.
D.It helps improve people’s lives.
【小题3】The acupuncture course the author took was         .
A.time-consuming and challenging
B.learner-centered and effective
C.difficult but interesting
D.painful but helpful
【小题4】What do the underlined words “other people” in the last paragraph refer to?
A.Other acupuncturists.
B.Other alternative therapists.
C.Other doctors who use Western medicine.
D.Other people who want to escape fro stress.

The medical world is gradually realizing that the quality of the environment in hospitals may play an important role in helping patients to get better.

As part of a nationwide effort in Britain to bring art out of the museums and into public places, some of the countries’ best artists have been called in to change older hospitals and to soften the hard edges of modern buildings. Of the 2,500 Nation Health Service hospitals in Britain, almost 100 now have very valuable collections of present art in passages, waiting areas and treatment rooms.

These recent movements were first started by one artist, Peter Senior, who set up his studio at a Manchester hospital in Northern England during the early 1700s. He felt that artist had lost his place in modern society, and that art should be enjoyed by a wider audience.

A common hospital waiting room might have as many as 5,000 visitors each week. What a better place to hold a regular exhibition of art! Senior held the first exhibition of his own paintings in the out-patients’ waiting area of the Manchester Royal Hospital in 1975. Believed to be Britain’s first hospital artist, Senior was so much in demand that he was soon joined by a team of six young art school graduates.

The effect is striking. Now in the passages and waiting rooms, the visitor experiences a full view of fresh colours, playful images and restful courtyards. The quality of the environment may reduce the need for expensive drugs when a patient is recovering from an illness. A study has shown that patients who had a view onto garden needed half the number of strong pain killers compared with patients who had no view at all or only a brick wall to look at.

【小题1】Some best artists have been gathered to ______.
A.pull down older hospitals and build up new ones
B.make the corners of the hospital buildings round
C.bring art into hospitals
D.help patients recover from illness
【小题2】Peter Senior is ______.
A.one of the best artists in Britain
B.a pioneer in introducing art into hospitals
C.one of the young art school graduates
D.a kind painter who brings only his paintings into hospitals
【小题3】From this text, we've learned that ______.
A.artists in Britain have completely lost their places in modern society
B.patients should be encouraged to learn art
C.hospitals in Britain should be changed into museums
D.art should be encouraged in Britain's hospitals
【小题4】After the improvement of hospital environment, ______.
A.patients no longer need drugs to kill their pains
B.patients needn’t buy any expensive drugs
C.patients need fewer pain killers when they are getting better after illness
D.patients can take fewer pills each time
【小题5】It can be inferred from this text that ______.
A.the role of hospital environment is being recognized
B.hospital artists have done a lot for patients
C.art exhibitions in hospitals attract more audience than those in museums
D.hospitals in Britain look more beautiful than those in other countries

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