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Scientists have successfully implanted and integrated human brain cells into newborn rats, creating a new way to study complex psychiatric disorders such as schizophrenia (精神分裂症), and perhaps eventually test treatments.

Scientists can assemble small sections of human brain tissue made from stem cells in a special container. But in such a container, “neurons(神经元) don’t grow to the size, to which a human neuron in an actual human brain would grow,” said Sergiu Pasca, the study’s lead author from Stanford University. To overcome such restrictions, researchers implanted the groupings of human brain cells, called organoids, into the brains of young rats.

Human neurons have also been implanted into adult rats before, but an animal’s brain stops developing at a certain age, limiting how well implanted cells can integrate. “By transplanting them at these early stages, we found that these organoids can grow relatively large and receive nutrients, and they can cover about a third of a rat’s brain,” said Pasca.

To test how well the human neurons integrated with the rat brains and bodies, air was blown out across the animals’ whiskers, which prompted electrical activity in the human neurons. That showed that external stimulation of the rat’s body was processed by the human brain tissue.

The scientists then conducted another test in the opposite order. They implanted human brain cells which could respond to blue light, and then trained the rats to expect a “reward” of water from a pipe when blue light shone on the neurons via a cable in the animals’ brain. After two weeks, they found pulsing the blue light sent the rats scrambling to the pipe.

The team has now used the technique to show that organoids developed from patients with Timothy syndrome grow more slowly and display less electrical activity than those from healthy people.

Tara Spires-Jones, a professor at the University of Edinburgh’s UK Dementia Research Institute, said the work “has the potential to advance what we know about psychiatric disorders.”

【小题1】Why did scientists research on rats instead of the special container?
A.Because psychiatric disorders are too complex.
B.Because rats also suffer similar psychiatric illnesses.
C.Because it limits the growth of human brain neurons.
D.Because human brain neurons grow too quickly in it.
【小题2】What can be inferred from Paragraph 3?
A.Rats’age has a significant influence on the research.
B.Human brain cells can’t be implanted into adult rats.
C.Rats’ brain won’t develop if they receive human neurons.
D.Human neurons can grow larger in adult rats’ brain than young rats’.
【小题3】Why did the researchers carry out one more test?
A.To train rats to respond to external stimulations.
B.To show similarities between rats and human tissues.
C.To confirm human brain cells could grow well in rats’ brains.
D.To check whether signals could be sent back to rats’ body.
【小题4】What is the significance of the research?
A.It can advance more experiments on rats.
B.It can further our study of psychiatric illnesses.
C.It can provide some useful experimental methods.
D.It can promote our knowledge of human brain cells.
22-23高三上·湖北·阶段练习
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Appealing to rich people's desire to control events is a better tactic to get them to donate to the charity, rather than their community spirit. That's the finding of a psychological study building on previous research which found that the wealthy people value the ability to control the outcome of different events compared to lower-income people.

Donations from high earners were 1.5 times larger when researchers tailored(定制)the words of letters requesting financial support to play on this desire.

Experts from Harvard University wrote to 12,000 alumni of an Ivy League business school—who were earning $ 100,000 (£ 80,000) per year or more—asking them to donate to the school. Two sets of letters were sent out—one saying the “community” needed to take action, while the other called on individual action. The letter were phrased respectively as "Sometimes, one community needs to come forward and support a common goal" or "Sometimes, one person needs to come forward and take individual action”.

Respondents to the second letter gave $ 432 (£ 340) on average compared to the $ 270 (£ 215) average from the first group.

New Scientist Ashley Whillans, who led the research, said, "We think that giving high-income earners a sense of control makes them want to give more.”

【小题1】What is the finding of the psychological study?
A.Community spirit is more important in getting donation.
B.Meeting wealthy people's desire of controlling events can get more donation.
C.Wealthy people do not care about their community spirit at all.
D.Lower-income people are more likely to control the result of events.
【小题2】What does the underlined word them refer to in the third paragraph?
A.experts.B.letters.
C.events.D.alumni.
【小题3】According to the passage, which of the following messages can get more donation?
A.Your help can benefit the blind boy.
B.Let's take action for a common goal.
C.It's necessary to help the blind boy.
D.Our community works together to help the blind boy.
【小题4】The author writes the passage in order to__________.
A.assist the poor to lead a meaningful life
B.stress the impact of the rich's controlling desire on donation
C.appeal to more people to focus on the poor's feeling
D.persuade the rich to donate more to the charity

For many, it is a journey that you will never give up, and the more you put in, the more you get out. While this kind of attitude may work for some, the latest scientific research suggests that it can also go wrong for many people.

Mauss has shown that seeking happiness can also increase feelings of loneliness and disconnection, perhaps because it causes you to focus your attention on yourself and your own feelings rather than appreciating the people around you. "Self-focus might make me engage with other people less,and I might judge other people more negatively if I think they ‘mess' with my happiness,”Mauss added.

These effects don't end there. Maglio at the University of,Toronto found another way that the conscious happiness-seeking may have the opposite effect: By leading us to feel that time is slipping away. Happiness comes from something pleasant that I can enjoy right now,to something burdensome(难以承担的)that I have to keep working at over and over and over," Maglio says.

“If you are constantly reminded of your friend enjoying at this beautiful location or at that delicious dinner,I think that might serve as a reminder that other people are happier than you-and kick-start(强力启动)that goal of happiness again. "

Mauss,meanwhile,points out that a lot of research has found that people who take a more “accepting” altitude to bad feelings-rather than constantly trying to fight them as the enemy--actually end up more satisfied with their life over the long-term. When you are trying to be happy,you may become judgmental and disapproving of bad things in your life. . . "For these reasons,she advises people to have a more stoic(苦修的)attitude to life's ups and downs,in which you accept bad feelings as events which last only a short time rather than trying to remove them entirely.

Happiness really is like a shy animal. And once you stop chasing it,you might just find that it appears naturally of its own accord.

【小题1】What does “it” in Paragraph I refer to?
A.Seeking happiness.B.Earning money.
C.Finding jobs.D.Gaining success.
【小题2】Why may happiness-seeking make people feel lonely?
A.They cannot ask help from others.
B.They have something important to do.
C.They feel other people are happier.
D.They care too much about themselves.
【小题3】What kind of people may feel less happy according to Maglio?
A.Feeling others happier and seeking the same happiness.
B.Having less time to seek happiness.
C.Having heavy work to do.
D.Making less money.
【小题4】How do we feel happy according to Mauss?
A.Make more money to enjoy life.B.Forget those happier than you.
C.Accept life as it is and contain it.D.Be a kind and helpful person.

1There are no reported sightings of teenage elephants hesitantly sitting down at the family dinner table with earphones in place, occasionally giving one-word answers to parents’ questions.

But they do exhibit other behaviors many parents of human teens would recognize, said Moss, a researcher who has studied elephants in Kenya’s National Park for nearly five decades.

“They’re naïve (天真的). They have a lot to learn and they make mistakes,” Moss said.

This is particularly true for males. She explained: They ruin crops. They get shot. They die. “It’s just like young human males who drive too fast,” Moss said, “and the insurance companies know very well to make them pay higher insurance rates.”

Barbara Natterson, a Harvard biologist pointed out that adolescent animals frequently put themselves in danger intentionally. This behavior is seen throughout the animal world. The adults of any species may consider some actions of their young low-judgment and high-risk; however, these actions actually serve a purpose.

An example is a practice called “predator (捕食者) inspection” which means adolescent animals approach predators rather than run away. The trade-off for the danger is that they can watch, smell and learn about the predator. They gather all kinds of information that can keep them safer as adults.

The idea that adolescents are hard-wired to take these risks can help people understand human teens’ behavior.

“Teens seem driven to try new things and test boundaries in their own version of ‘predator inspection’,” Natterson said. “They try to have as many experiences as they can before they leave the nest.”

Another key aspect of adolescence is an increase in time spent wandering in groups. Adolescence is marked by high levels of peer pressure as well as near-disaster. Scientists have found that adolescents of all kinds are more likely to make dangerous moves while with peers.

Laurence Steinberg, a psychology professor at Temple University, found mice and human group adolescent behavior has something in common. He set up two experiments. One involved mice, half of which were adolescents, drinking ethanol-spiked (添加乙醇的) water. The other involved human teens playing a video game reproducing driving conditions.

“We found that in the presence of peers, adolescent mice drank more than they do when they’re alone,” Steinberg said, “and that the teenagers in the driving study also took more risks when others were around.”

2These findings fit with what Steinberg says is another multi-species adolescent quality: the desire to socialize.

“For the most part, adolescents, human and animal alike, prefer to be with other adolescents,” Steinberg said. “If I say teenagers are social animals, I think the word ‘animal’ is just as important in that sentence as the word ‘social’.”

Both Natterson and Steinberg hope their findings will help people who are raising adolescents.

【小题1】According to Natterson, what is a risky but valuable action for adolescent animals?
A.Gathering information with the help of parents.
B.Challenging predators with other adolescents.
C.Observing an adult hunting a large animal.
D.Watching enemies’ behavior up close.
【小题2】Steinberg’s experiments found ________.
A.peer pressure is more common in adolescent animals than in human teens
B.both adolescent animals and human teens are affected by peer pressure
C.adolescent animals are less likely to get drunk while with peers
D.teenagers are not willing to be sociable in the presence of peers
【小题3】What does the underlined sentence mean?
A.Adolescent animals long to socialize with teenagers.
B.“Social” is a word that can be interpreted in different ways.
C.Socializing with peers is one quality that adolescents share.
D.The importance of socializing has been realized by teenagers.

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