Directions: After reading the passage below, fill in the blanks to make the passage coherent and grammatically correct. For the blanks with a given word, fill in each blank with the proper form of the word; for the other blanks, use one word that best fits each blank. New Gene Therapy Partially Restores Sight to Blind Man
Researchers inserted genes that code for light-sensitive proteins in seaweed into the man’s retina(视网膜), and now he reports limited but much improved vision. Researchers say they 【小题1】(restore)limited vision in a blind man using a new type of gene therapy. The study, published this week in the journal Nature Medicine, used a gene for light—detecting proteins taken from a type of seaweed 【小题2】(rebuild)nerve cells in the man’s eye. “Seeing for the first time that it did work, 【小题3】only in one patient and in one eye is exciting,“ Ehud Isacoff, a neuroscientist at the University of California tells Carl Zimmer of the New York Times.
The man’s restored vision can’t be described as full vision, as he still can’t see colours or pick out faces or letters. But 【小题4】the 58-year-old man who suffers from a genetic disease called retinitis pigmentosa(色素性视网膜炎), could only barely detect light before the procedure, he can now perceive and count objects. The study presents the first instance of the new technique, called optogenetics, successfully 【小题5】(use)to treat a human patient.
To partially restore the man’s sight, researchers inserted the gene that codes for light-sensitive proteins 【小题6】(find)in seaweed and bacteria into the cells at the back of one of his eyes. With the genetic instructions for making opsins(视蛋白)inserted into his eye, these new opsins in the man’s eye send electrical signals to his brain 【小题7】they are exposed to light and subsequently change shape. The catch is that these opsins only respond to amber coloured light, which is 【小题8】the special glasses were necessary. Getting this system to work also required some seven months of training the volunteer’s brain to recognize and make sense of the new signals it was getting. This practice involved wearing the glasses at home and on walks. 【小题9】the seven-month mark, the man, who lives in France, excitedly realized he could see the white stripes of a crosswalk.
Botond Roska, a neuroscientist and gene therapist, holds the belief 【小题10】their technique is not a cure for blindness: ”For now, all we can say is that there is one patient with a functional difference.” Still, he believes this clinical result is “a milestone on the road to even better outcomes”.